|
KMID : 0869619910080030166
|
|
Journal of Korean Society of Hospital Pharmacists
1991 Volume.8 No. 3 p.166 ~ p.170
|
|
|
Dissolution Rate and Content Uniformity of Diltiazem hydrochloride Tablets
|
|
文洪燮
李鍾機/崔仁/柳在坤/沈美敬/崔正喜/崔俊植
|
|
|
Abstract
|
|
|
|
Drug effect is depend on bioavailability of preparation and also bioavailability is largely depend on dissolution rate. This study was attempted to evaluate bioavailability of preparations for drug choice among many preparations by the dissolution test and content uniformity test of commercial diltiazem hydrochloride tablets. The dissolution test was conducted in aquas, artificial gastric juice, and artificial intestinal juice using Basket method with four diltiazem hydrochloride preparations(A,B,C,D) which were pharmaceutically equivalent. The results were as follows: 1) The dissolution rate in aquas and artificial gastric juice was higher in the order of four different brands D〉C〉A〉B. 2) Content uniformity of four different brands was better in such order as B〉C〉A〉D. 3) There was no relationship between dissolution rate and content uniformity.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|